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. 2019 Dec 19;4(24):e132402. doi: 10.1172/jci.insight.132402

Figure 4. Pulsatile weekly prednisone requires epigenetic remodeling.

Figure 4

(A) Coadministration of anacardic acid, a histone acetyl-transferase inhibitor, blunted gain of H3K27ac marking in identified GRE, KRE, and MEF2 sites in muscle observed after weekly prednisone. (B) Coadministration of prednisone and anacardic acid blunted gains in oxygen consumption rates with glucose, palmitate, or valine. (C) Coadministration of prednisone and anacardic acid blunted gains in muscle force (Tibialis anterior). Histograms depict single values and mean ± SEM; n = 3 mice/group (C). *P < 0.05 vs. vehicle, 1-way ANOVA with Tukey’s multiple comparison.