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. 2019 Dec 19;4(24):e130540. doi: 10.1172/jci.insight.130540

Figure 10. BCG revaccination significantly induces Mtb-specific regulatory IL-10+ Th17 responses.

Figure 10

CD4+ T cell subsets expressing IL-17A, IL-17F, or IL-22 (Th17) — either in combination with IFN-γ or IL-10 from BCG-revaccinated IGRA+ and IGRA– subjects (Groups 1 and 2, n = 10) — were compared with unvaccinated control IGRA+ and IGRA– subjects (Groups 3 and 4, n = 10) at T5 to Ag85A, BCG, and LTAg stimulation. For this analysis, we calculated cytokine-positive cells based on the gating shown in Supplemental Figure 6. Statistical analysis was performed using a 1-way ANOVA with Bonferroni post hoc test defining differences as significant (*P < 0.05).