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. 2019 Dec 19;4(24):e129756. doi: 10.1172/jci.insight.129756

Figure 2. Tregs infiltrating human metastatic melanoma express high levels of arginase 2.

Figure 2

(A) Heat map of significantly different gene counts (normalized by row) comparing cutaneous melanoma tissue Tregs with cutaneous melanoma tissue Teffs (P < 0.05, Wald test). (B) Volcano plot of statistical significance (Wald test) vs. fold-change comparing skin Treg RNA-Seq profiles from cutaneous melanoma tissue Tregs with cutaneous melanoma tissue Teffs. ARG2 is indicated in red. (C) Normalized RNA-Seq counts of samples depicted in A. (*P < 0.0003, Wald test). (D) Flow cytometric quantification of ARG2 protein expression in Tregs isolated from healthy skin or cutaneous metastatic melanoma lesions from 7 to 8 independent donors (*P < 0.05, unpaired t test; ***P < 0.001, paired t test).