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. 2019 Dec 19;4(24):e129756. doi: 10.1172/jci.insight.129756

Figure 4. Treg expression of arginase 2 maintains Tregs in tissues.

Figure 4

(A) Schematic of adoptive transfer of Arg2 overexpressing Tregs or control Tregs into FOXP3-DTR mice. (B) Representative flow plot of viral expression (mKate+) gate in skin and skin-draining lymph node cells isolated after adoptive transfer and host Treg depletion (gated on transferred CD45.1+ Tregs). (C) Cell counts and percentage of skin and skin-draining lymph node transferred Tregs expressing control vector or Arg2 vector, normalized to input (gated on transferred CD45.1+ events). Experiment is representative of 3 independent studies (*P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001, unpaired t test). (D) %Ki67+ and Ki67 MFI of CD45.1+ transferred events expressing control vector or Arg2 vector in the skin-draining lymph node and skin. Experiment is representative of 3 independent studies.