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. 2019 Dec 19;4(24):e129756. doi: 10.1172/jci.insight.129756

Figure 7. Treg expression of arginase 2 suppresses mTOR signaling.

Figure 7

(A and B) Flow cytometric analysis of pS6 expression on human Tregs expanded in vitro with increasing doses of the arginase inhibitor S-(2-boronoethyl)-L-cysteine (BEC). Rapamycin was used as a control to inhibit mTOR signaling (*P < 0.05, ***P < 0.005, ordinary 1-way ANOVA, data are representative of 3 independent experiments). (C) Flow cytometric analysis of pS6 expression on mouse Tregs expanded in vitro and transduced with a retrovirus expressing either Arg2 or an empty vector control. Data were collected on day 2 or day 5 after transduction. Rapamycin was used as a control to inhibit mTOR signaling. Data are representative of 2 independent experiments.