Figure 2.

Summary of the frequency and amplitude of sEPSCs during Panx1 block and Schaffer collateral stimulation. A, All Shaffer collateral PPS was delivered at 0.05 Hz (20 s inter-PPS interval). Block of Panx1 with either α-panx1 in the pipette or ¹⁰panx (100 μm) in the bath augmented sEPSC frequency following afferent stimulation. There is a lack of effect of the respective controls, α-Cx43 and sc¹⁰panx. *p < 0.05 (nonparametric Wilcoxon matched-pairs signed rank test). B, Summary of the sEPSC amplitudes under control (n = 12) and with α-panx1 (n = 31) in the pipette in the presence or absence of PPS as indicated. A within-cell design was used as for the frequency analysis, and no significant difference was detected. C, Comparison of different inter-PPS intervals as indicated above each bar. Frequency was determined for the entire 5 min recordings and was significantly increased at 10 and 30 s inter-PPS intervals.