Figure 6.

Blockers of CB1 receptors and nitric oxide synthase do not prevent the Panx1 block induced facilitated glutamate release. A, B, Exemplar recordings from two different CA1 neurons testing the role of the retrograde transmitter receptor, CB1R, and nNOS in synaptic bursting. Both were ruled out because application of their specific antagonists, AM251 and l-NAME, respectively, did not alter the appearance of increased sEPSC frequency. C, Summary of the mean sEPSC frequency. *p < 0.05 (Wilcoxon matched-pairs signed rank test).