Table 3.
Molecularly defined neuron subtypes |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sox6+ |
Nkx2.1+ |
PV+ |
Lhx6+ |
Npas1+ |
Foxp2+ |
Dbx1+ |
ChAT+ |
|||||||||
Median ± MAD | n (neurons; sections) | Median ± MAD | n (neurons; sections) | Median ± MAD | n (neurons; sections) | Median ± MAD | n (neurons; sections) | Median ± MAD | n (neurons; sections) | Median ± MAD | n (neurons; sections) | Median ± MAD | n (neurons; sections) | Median ± MAD | n (neurons; sections) | |
Total GPe neurons (%) | 63.7 ± 4.0 | 4681; 14 | 59.6 ± 2.3 | 5342; 16 | 49.2 ± 4.3 | 2726; 19 | 33.7 ± 7.5 | 2533; 12 | 32.1 ± 3.9 | 3361; 21 | 22.1 ± 1.1 | 1273; 10 | 9.3 ± 1.3 | 3002; 61 | 5.9 ± 1.7 | 267; 9 |
Coexpression (%) | ||||||||||||||||
Sox6 | – | – | 68.2 ± 0.5 | 681; 3 | 52.5 ± 8.4 | 1675; 15 | c75.5 ± 7.2 | 2346; 15 | 93.4 ± 5.6 | 1999; 14 | 67.0 ± 4.3 | 206; 3 | 51.6 ± 8.2 | 442; 15 | 0.0 ± 0.0 | 0; 3 |
Nkx2.1 | 58.2 ± 0.3 | 681; 3 | – | – | 83.2 ± 3.5 | 1105; 7 | 78.4 ± 8.0 | 1469; 9 | 32.0 ± 1.4 | 383; 6 | 0.0 ± 0.0 | 1; 3 | 77.8 ± 10.2 | 329; 9 | – | – |
PV | 36.4 ± 3.2 | 1675; 15 | 70.8 ± 3.0 | 1105; 7 | – | – | a28.1 ± 7.3 | 654; 12 | 2.7 ± 2.7 | 96; 12 | – | – | 72.0 ± 8.3 | 493; 23 | – | – |
Lhx6 | 47.0 ± 6.7 | 2346; 15 | 40.6 ± 7.4 | 1469; 9 | 24.1 ± 9.6 | 654;12 | – | – | 40.7 ± 4.6 | 818; 12 | 1.3 ± 1.3 | 8; 3 | – | – | 50.0 ± 3.6 | 48; 3 |
Npas1 | 45.4 ± 5.7 | 1999; 14 | 17.3 ± 2.3 | 383; 6 | 2.0 ± 2.0 | 96; 12 | b35.2 ± 5.1 | 818; 12 | – | – | 79.3 ± 3.8 | 566; 6 | 9.5 ± 5.2 | 72; 14 | – | – |
Foxp2 | 34.1 ± 5.7 | 206; 13 | 0.0 ± 0.0 | 1; 3 | – | – | 1.9 ± 0.5 | 8; 3 | 56.8 ± 4.2 | 566; 6 | – | – | 3.6 ± 1.9 | 13; 10 | – | – |
Dbx1 | 10.4 ± 3.2 | 411; 15 | 12.0 ± 1.3 | 329; 9 | 13.6 ± 3.0 | 493; 23 | – | – | 3.3 ± 1.8 | 72; 14 | 1.5 ± 0.6 | 13; 10 | – | – | 10.6 ± 4.2 | 34; 9 |
ChAT | 0.0 ± 0.0 | 0; 3 | – | – | – | – | f6.7 ± 0.6 | 48; 3 | – | – | – | – | 7.4 ± 3.3 | 34; 9 | – | – |
Lhx6+ neuron composition: a + b + d + e = 100%.
aLhx6+-PV+ = 28%.
bLhx6+-Npas1+ = 35%.
cLhx6+-Sox6+ = 76%.
dLhx6+-PV−-Npas1−-Sox6−: 100% − c = 24%.
eLhx6+-PV−-Npas1−-Sox6+: c − a − b = 13%.
fChAT+ neurons can be a portion of Lhx6+-PV−-Npas1−-Sox6− neurons.
Lhx6+-PV+ and Lhx6+-Npas1+ neurons also express Sox6.
MAD, Median absolute deviation.