Fig 12.

DWI changes after anti-VEGF agent administration in patients with GBM. Axial DWI (A) and an ADC map (B) show markedly restricted diffusion (lowest ADC = 0.5 × 10⁻⁶ mm²/s) in the right periventricular white matter (arrowheads), soon after bevacizumab was started in a patient with recurrent GBM. C, Axial contrast-enhanced T1-weighted image shows only thin rim enhancement in the area of restricted diffusion (asterisk). Those findings most likely represent ischemic changes within the tumor and should not be confused with progressive disease. The ADC measurements were obtained by drawing a circular ROI in the visually lowest ADC areas on the ADC map.