Imaging features of the nonenhacing component of glial tumors. A 36-year-old man underwent partial resection and adjuvant radiation therapy of an extensive diffuse astrocytoma (World Health Organization, grade II) involving both parietal lobes (not shown). A, Axial FLAIR image obtained 5 years after completion of radiation therapy demonstrates extensive hyperintensity crossing the midline through the splenium of the corpus callosum (arrows), probably representing a mixture of lower-grade tumor and radiation injury. B, Axial FLAIR image obtained 8 months later depicts blurring of the gray-white matter in the left parietal lobe (arrowheads), as well as effacement of the left lateral ventricle (asterisk), which is consistent with neoplastic infiltration (progressive disease).