Fig 7.

A progressive low-grade glioma in a 33-year-old man previously diagnosed with Li-Fraumeni syndrome. Initial axial FLAIR (A) and contrast-enhanced T1-weighted (B) images showed subtle cortical-subcortical FLAIR hyperintensity in the left inferior parietal lobule, with minimal expansive effect and no postcontrast enhancement, which was presumably considered to be a low-grade glial tumor (arrowhead). Two years later, axial FLAIR (C) and contrast-enhanced T1-weighted (D) images depict a marked increase in the expansive effect, with loss of gray-white matter differentiation and heterogeneous enhancement (arrowhead). Those findings are consistent with malignant transformation of a lower-grade glioma (progressive disease).