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(a) Architecture of the full-length IP3 receptor (PDB: 6dqj). Domains are colored by red (SD), blue (IBCβ), green (IBCα), yellow (HD), and cyan (CD). (b) Crystal structures of IP3-bound (colored, PDB: 3uj0) and -unbound (gray, PDB: 3uj4) forms of IBC/SD. IBCβ of the two structures are superimposed. IP3 is also shown by orange sticks. Domain motions via IP3 binding are depicted by arrows.
