Survival analysis according to molecular classification. In the training cohort (A), groups 1 (microsatellite instability [MSI]+) and 2 (Epstein‐Barr virus [EBV]−, MSI−, non‐epithelial‐mesenchymal transition [non‐EMT]‐like, p53−) showed the best survival outcome, groups 3 (EBV+) and 4 (EBV−, MSI−, non‐EMT‐like, p53+) showed intermediate prognosis, and group 5 (EBV−, MSI−, EMT‐like) was noted for poor prognosis (p < .001). Similar patterns of differences in overall survival were recapitulated in the validation cohort (p = .004) (B) and the combined cohort (p < .001) (C).
Abbreviation: OS, overall survival.