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. 2020 Jan 22;6(4):eaaw6938. doi: 10.1126/sciadv.aaw6938

Fig. 2. Morphological phenotypes in vitro and differential tumor progression in vivo.

Fig. 2

(A and B) Scatter plot showing both tumor size and the extent of lung metastasis resulting from the injection of 14 SCCs and parental MDA-MB-231 cells into the mammary pad of SCID mice. At least four mice were tested for each SCC (A). The number within each circle represents the morpho-type class of the corresponding SCC. On the basis of tumorigenicity and metastatic burden in the lung, these SCCs were further classified into four groups: low tumorigenicity (LT), tumorigenic (T), metastatic (M), and hypermetastatic (HM). The Pearson’s correlation coefficient between the effective metastasis and tumor weight among all SCCs is 0.32. The number of circulating tumor cells (CTCs) is highly correlated with lung metastasis, with a correlation coefficient of 0.96 (B). (C) Histological sections of mice lung show that clear metastatic lesions are present for SCC-M6-1308, SCC-M6-1319, and parental cells, but not in other SCCs, including SCC-M2-1012, SCC-M2-1304, and SCC-M2-1022. au, arbitrary units.