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. Author manuscript; available in PMC: 2020 Jan 22.
Published in final edited form as: Nat Rev Genet. 2019 Oct 21;21(1):5–26. doi: 10.1038/s41576-019-0175-6

Fig. 2. Tile assembly of DNA nanostructures.

Fig. 2

A| Different Seeman tiles with diverse strand polarities34. B| Principles of ssDNA brick assembly: each brick is a DNA single strand with four domains. When each domain is 8 nucleotides long, its hybridization with an adjacent brick produces a dihedral angle of 90 °. Each brick could be thought as a LEGO binding to four other complementary LEGOs to form a cube61. C| The design workflow starts with removing 3D pixels (voxels) from a 3D canvas followed by generation of the corresponding strand diagram and sequences64. D| Transmission electron microscopy (TEM) characterization of designed arbitrary shapes and geometries (scale bars 100 nm)64. Panels A-C were adapted from REFs. 61, 64, 64, respectively, with permissions from AAAS and Springer Nature. DX, double-crossover; JX, juxtaposed crossover; PX, paranemic crossover; TX, triple-crossover,