Figure 4.

Summary of the status of each patient from baseline during the course of the treatment until the evaluation of PD by radiological imaging. Mutation – denotes the absence of somatic mutations. Mutation + denotes the detection of somatic mutations. Green circles denote molecular PD, wherein new mutations or significant increases in allele fraction of existing mutations were detected. Yellow triangles denote PD predicted by a lung cancer early detection model. Red circles denote PD predicted by a methylation ratio model. Numbers in parenthesis beside the patient numbers indicate the methylation trend groupings. PD, disease progression.