Skip to main content
. 2019 Dec;8(6):862–875. doi: 10.21037/tlcr.2019.11.04

Figure 4.

Figure 4

Circ-ZKSCAN1 can sponge and suppress miR-330-5p in NSCLC cells. (A,B) The relative indications of 4 miRNA expressions in NSCLC cells after transfection with the knock-down circ-ZKSCAN1 or control group. (C,D) Circ-ZKSCAN1-wild- or -mutant-type luciferase vector after transfection with miR-330-5p or control mimics in A549 and H1299 cells by luciferase activity. (E,F) Four indicated miRNA expressions after RNA pull-down assay with circ-ZKSCAN1 probe and control probe in A549 and H1299 cells. (G) MiR-330-5p expression in control or OE-circ-ZKSCAN1 A549 and H1299 cells. (H, I, J) Relative expression levels of miR-330-5p in xenografts of nude mice (H), NSCLC cells (I), and tissues (J). (K) The OS probability of NSCLC patients with low- and high-miR-330-5p expression. (L) The correlation between circ-ZKSCAN1 and miR-330-5p expression in NSCLC tissues. (*P<0.05, **P<0.01, ***P<0.001). NSCLC, non-small cell lung cancer.