Table 5. COX regression analysis of OS.

Variables	Univariate				Multivariate
	Odds ratio	95% CI	P		Odds ratio	95% CI	P
Age (<70 vs. ≥70)	0.833	0.512–1.356	0.463
Gender (female vs. male)	2.107	1.170–3.794	0.013*		1.729	0.949–3.149	0.073
Smoking status (non-smoker vs. smoker)	0.619	0.251–1.527	0.298
T (1–2 vs. 3–4)	2.114	1.354–3.300	0.001*		1.221	0.737–2.024	0.439
N (0 vs. 1–2)	1.973	1.306–2.981	0.001*		0.94	0.509–1.738	0.845
M (0 vs. 1)	4.348	1.959–9.650	<0.001*		1.745	0.733–4.156	0.209
Stage (I–II vs. III–IV)	3.949	2.578–6.051	<0.001*		3.393	1.686–6.829	0.001*
Grade (1 vs. 2–3)	0.788	0.425–1.462	0.449
TIM-3 on tumor cells (negative vs. positive)	1.236	0.671–1.310	0.616
TIM3 on TILs (negative vs. positive)	2.012	0.671–1.311	0.038*		1.179	0.592–2.347	0.64

*, P<0.05 indicates statistical significance. OS, overall survival; TIL, tumor infiltrating lymphocyte.