Table 6. COX regression analysis of RFS in stage I–II patients.
| Variables | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | P | Odds ratio | 95% CI | P | ||
| Age (<70 vs. ≥70) | 0.795 | 0.424–1.490 | 0.474 | ||||
| Gender (female vs. male) | 1.620 | 0.811–3.239 | 0.172 | ||||
| Smoking status (non-smoker vs. smoker) | 0.465 | 0.167–1.294 | 0.143 | ||||
| T (1–2 vs. 3–4) | 1.330 | 0.626–2.826 | 0.459 | ||||
| N (0 vs. 1–2) | 1.345 | 0.728–2.483 | 0.344 | ||||
| M (0 vs. 1) | – | – | – | ||||
| Stage (I–II vs. III–IV) | – | – | – | ||||
| Grade (1 vs. 2–3) | 0.479 | 0.229–1.001 | 0.050* | 0.549 | 0.255–1.185 | 0.126 | |
| TIM-3 on tumor cells (negative vs. positive) | 0.902 | 0.219–3.711 | 0.886 | ||||
| TIM3 on TILs (negative vs. positive) | 3.013 | 1.279–7.097 | 0.012* | 2.562 | 0.872–7.522 | 0.087 | |
*, P<0.05 indicates statistical significance. RFS, recurrence-free survival; TIL, tumor infiltrating lymphocyte.