Table S1. Univariate and multivariate analysis for prediction of TIM-3 expression on tumor cells in NSCLC patients.

Variables	Univariate				Multivariate
	Odds ratio	95% CI	P		Odds ratio	95% CI	P
Age (<70 y vs. ≥70 y)	2.667	0.673–10.564	0.163
Sex (female vs. male)	2.297	0.276–19.127	0.442
Smoking status (nonsmoker vs. smoker)	0.32	0.033–3.075	0.324
Pathological type (non-adenocarcinoma vs. adenocarcinoma)	1.257	0.299–5.290	0.755
Stage (I–II vs. III–IV)	2.713	0.692–10.634	0.152
PD-L1 on tumor cells (negative vs. positive)	5.318	1.298–21.785	0.02*		5.318	1.298–21.785	0.02*
PD-1 on TILs (negative vs. positive)	0.64	0.153–2.672	0.541
PD-L1 on TILs (negative vs. positive)	0.488	0.097–2.455	0.383

*, P<0.05 indicates statistical significance. NSCLC, non-small cell lung cancer; TIL, tumor infiltrating lymphocyte.