Table 2. Estimates for hazard ratios for overall survival from first and second line treatment.

Group	Timepoint	Hazard ratio (95% CI)	P value	C-stat
NLR	Baseline (n=276)	1.022 (1.014 to 1.029)	<0.001	0.656
	Second line (n=221)	1.095 (1.038 to 1.122)	<0.001	0.649
PLR	Baseline (n=276)	1.001 (1 to 1.001)	<0.001	0.591
	Second line (n=223)	1 (0.9991 to 1)	0.23	0.593
LMR	Baseline (n=275)	0.867 (0.715 to 0.995)	<0.01	0.576
	Second line (n=217)	0.873 (0.741 to 1.028)	0.10	0.562
ALI	Baseline (n=276)	0.957 (0.940 to 0.981)	<0.001	0.67
	Second line (n=189)	1.002 (0.999 to 1.004)	0.18	0.627