Table S3. Demographic characteristics associated with patients who yielded BALF EV-based EGFR genotyping (+)a.
| No | Sex | Age | Histological subtype | Tumor location | Size (mm) | Sample collection method (tissue/cytology) | BFS cytology | Location of BAL | Open bronchus sign | BALF EV-based genotype | TNM stage | Treatment | EGFR-TKI | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 75 | ADC | RUL | 20 | Surgery | No malignant cell | RB1 | Yes | L861Q | IA2 | Surgery | Not done | |
| 2 | M | 70 | ADC | LLL | 12 | Surgery | No malignant cell | LB8 | Yes | Exon 19 del | IIIA | Surgery, adjuvant chemoRx | Not done | |
| 3 | F | 67 | NSCLC | RUL | 51 | EBUS-TBNA | No malignant cell | RB2 | No | Exon 19 del | IIIB | Afatinib | Afatinib 14 days | Transfer |
| 4 | M | 67 | SQCC | RUL | 34 | EBUS-TBNA | SQCC | RB1 | Yes | G719S | IIIB | CCRT | Not done | |
| 5 | M | 85 | SQCC | Lingular | 20 | Bronchoscopy | SQCC | LB4 | No | Exon 19 del | IIIC | Tx refuse | Not done | |
| 6 | F | 77 | NSCLC | LUL | 55 | PCNB | No malignant cell | LB3 | Yes | Exon 19 del | IVA | Tx refuse | Not done | |
| 7 | M | 80 | ADC | RUL | 11 | Bronchoscopy | ADC | RB1 | Yes | Exon 19 del | IVA | ChemoRx | Not done | |
| 8 | F | 61 | NSCLC | RUL, RLL | 39, 21 | PCNB | No malignant cell | RB2 | Yes | Exon 19 del | IVB | After ChemoRx, Erlotinib | Erlotinib 42 days | Transfer |
| 9 | M | 83 | ADC | Lingular | 60 | PCNB | No malignant cell | LB4 | Yes | Exon 19 del | IVB | After ChemoRx, Gefitinib | Gefitinib 5 days | Death |
| 10 | M | 77 | NSCLC | LUL | 70, 42 | PCNB | No malignant cell | LB2 | No | Exon 19 del | IVB | ChemoRx | Not done | Transfer |
| 11 | M | 56 | NSCLC | RUL | 25 | EBUS-TBNA | No malignant cell | RB2 | Yes | Exon 19 del | IVB | ChemoRx | Not done | Transfer |
a, BALF EV-based genotyping (+) indicates negative results for EGFR-TKI sensitive mutation when tested with tissue/cytology but positive BALF. BALF, bronchoalveolar lavage fluid; EV, extracellular vesicles; ADC, adenocarcinoma; EBUS-TBNA, endobronchial ultrasound guided transbronchial needle aspiration; PCNB, percutaneous needle biopsy; BFS, bronchofiberscopy; RB, right bronchus; LB, left bronchus; del, deletion.