Table S3. Expression of 84 genes involved in inflammasome signaling (RT2 Profiler PCR Array-PAHS-097ZA-2) on mRNA level.
| Gene symbol | Gene name | Level of regulation (fold-change) |
|---|---|---|
| Up-regulated genes | ||
| CARD18 | Caspase recruitment domain family member 18 | 143.07 |
| AIM2 | Absent in melanoma 2 | 10.44 |
| PANX1 | Pannexin 1 | 8.4 |
| FADD | Fas associated via death domain | 8.02 |
| MOK | MOK protein kinase | 7.37 |
| IRAK1 | Interleukin 1 receptor associated kinase 1 | 6.93 |
| TNFSF4 | Tumor necrosis factor superfamily member 4 | 5.96 |
| NFKBIB | NFKB inhibitor beta | 5.9 |
| MAPK13 | Mitogen-activated protein kinase 13 | 5.44 |
| NOD2 | Nucleotide binding oligomerization domain containing 2 | 5.14 |
| HSP90AB1 | Heat shock protein 90 alpha family class B member 1 | 4.88 |
| NLRX1 | NLR family member X1 | 4.83 |
| HSP90B1 | Heat shock protein 90 beta family member 1 | 4.37 |
| MAPK12 | Mitogen-activated protein kinase 12 | 4.37 |
| RELA | RELA proto-oncogene. NF-kB subunit | 3.76 |
| BCL2L1 | BCL2 like 1 | 3.74 |
| XIAP | X-linked inhibitor of apoptosis | 3.51 |
| MAP3K7 | Mitogen-activated protein kinase 7 | 3.36 |
| PEA15 | Phosphoprotein enriched in astrocytes 15 | 3.13 |
| HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | 3.05 |
| MAPK9 | Mitogen-activated protein kinase 9 | 3.03 |
| MAPK1 | Mitogen-activated protein kinase 1 | 2.95 |
| TRAF6 | TNF receptor associated factor 6 | 2.9 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 2.86 |
| CXCL1 | C-X-C motif chemokine ligand 1 | 2.83 |
| SUGT1 | SGT1 homolog. MIS12 kinetochore complex assembly cochaperone | 2.72 |
| TAB1 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 | 2.65 |
| IL18 | Interleukin 18 | 2.59 |
| IKBKG | Inhibitor of kappa light polypeptide gene enhancer in B-cells. kinase gamma | 2.46 |
| RIPK2 | Receptor interacting serine/threonine kinase 2 | 2.33 |
| CCL2 | C-C motif chemokine ligand 2 | 2.3 |
| PYCARD | PYD and CARD domain containing | 2.27 |
| CHUK | Conserved helix-loop-helix ubiquitous kinase | 2.16 |
| IL1B | Interleukin 1 beta | 2.05 |
| MAPK8 | Mitogen-activated protein kinase 8 | 2.02 |
| CTSB | Cathepsin B | 2.02 |
| Down-regulated genes | ||
| IL33 | Interleukin 33 | −11.52 |
| IL6 | Interleukin 6 | −8.29 |
| NLRP9 | NLR family pyrin domain containing 9 | −5.98 |
| CD40LG | CD40 ligand | −3.93 |
| IL12A | Interleukin 12A | −3.53 |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | −2.64 |
| TXNIP | Thioredoxin interacting protein | −2.36 |
| CXCL2 | C-X-C motif chemokine ligand 2 | −2.29 |
| MEFV | Mediterranean fever | −2 |
| Genes with no change in expression | ||
| BIRC2 | Baculoviral IAP repeat containing 2 | 1.95 |
| MAPK3 | Mitogen-activated protein kinase 3 | 1.89 |
| IRF2 | Interferon regulatory factor 2 | 1.8 |
| NFKB1 | Nuclear factor kappa B subunit 1 | 1.75 |
| CASP5 | Caspase 5 | 1.65 |
| CASP1 | Caspase 1 | 1.62 |
| IL12B | Interleukin 12B | 1.51 |
| NFKBIA | NFKB inhibitor alpha | 1.5 |
| IFNG | Interferon gamma | 1.49 |
| IFNB1 | Interferon beta 1 | 1.46 |
| TIRAP | TIR domain containing adaptor protein | 1.39 |
| IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells. kinase beta | 1.39 |
| CARD6 | Caspase recruitment domain family member 6 | 1.27 |
| NLRP6 | NLR family pyrin domain containing 6 | 1.21 |
| IRF1 | Interferon regulatory factor 1 | 1.2 |
| MYD88 | Myeloid differentiation primary response 88 | 1.17 |
| NLRP1 | NLR family pyrin domain containing 1 | 1.08 |
| NOD1 | Nucleotide binding oligomerization domain containing 1 | −1.04 |
| NLRC5 | NLR family CARD domain containing 5 | −1.06 |
| P2RX7 | Purinergic receptor P2X 7 | −1.25 |
| CASP8 | Caspase 8 | −1.31 |
| NLRP12 | NLR family pyrin domain containing 12 | −1.39 |
| NLRP3 | NLR family pyrin domain containing 3 | −1.41 |
| CCL5 | C-C motif chemokine ligand 5 | −1.41 |
| MAPK11 | Mitogen-activated protein kinase 11 | −1.45 |
| TNF | Tumor necrosis factor | −1.49 |
| CFLAR | CASP8 and FADD like apoptosis regulator | −1.53 |
| NLRC4 | NLR family CARD domain containing 4 | −1.64 |
| CIITA | Class II major histocompatibility complex transactivator | −1.71 |
| PSTPIP1 | Proline-serine-threonine phosphatase interacting protein 1 | −1.73 |
| NAIP | NLR family apoptosis inhibitory protein | −1.76 |
| BIRC3 | Baculoviral IAP repeat containing 3 | −1.79 |
Shown are the fold change values in arbitrary units. Data were normalized to B2M housekeeping gene.