Table 3. Quality assessment utilizing QUADAS-2.

Author-year	Risk of bias					Applicability Concerns
	Patient selection	Index test	Reference standard	Flow and timing		Patient selection	Index test	Reference standard
Madan et al., 2016	Low	Low	High	Low		Low	Low	High
Yarmus et al., 2011	Low	Low	Low	Low		Low	Low	Low
Oki et al., 2013	Low	Low	High	Low		Low	Low	High
Trisolini et al., 2015	Low	Low	Unclear	Unclear		Low	Low	Unclear
Trisolini et al., 2011	Low	Low	Low	Low		Low	Low	Low
Murakami et al., 2013	High	Low	Low	Low		High	Low	Low
Li et al., 2014	High	Low	Low	Low		High	Low	Low
Bruno et al., 2013	Low	Low	Low	Low		Low	Low	Low
Gianella et al., 2018	Low	Low	Low	Unclear		Low	Low	Low
Cardoso et al., 2015	Low	Low	High	Low		Low	Low	High
Mondoni et al., 2013	High	Low	Low	Low		High	Low	Low
Baram et al., 2005	Unclear	Low	Low	Low		Unclear	Low	Low
Chen et al., 2015	Low	Low	High	High		Low	Low	High
Diette et al., 2000	Low	Low	High	Low		Low	Low	High
Austin et al., 1993	High	Low	Low	Low		High	Low	Low
Santambrogio et al., 1997	Low	Low	Low	Low		Low	Low	Low
Saleh et al., 1996	Unclear	Low	High	Unclear		Unclear	Low	High
Küçük et al., 2004	High	Low	Unclear	Low		Low	Low	Low
Davenport et al.1990	Low	Low	High	Low		Low	Low	High
Collins et al., 2012	Low	Low	High	Low		Low	Low	High
Griffin et al., 2010	Low	Low	Low	Low		Low	Low	Low
Guo et al., 2015	Low	Low	Low	Low		Low	Low	Low
Xiang et al., 2018	Low	Low	High	Low		Low	Low	High
Chaiyakul et al., 2018	Low	Low	Low	Low		Low	Low	Low
Wong et al., 2014	Low	Low	High	Low		Low	Low	High
Kern et al., 2012	Low	Low	Unclear	Unclear		Low	Low	Unclear