Table 3. Competing risk analyses of clinical-pathological factors and IHC markers associated with loco-regional recurrence.
| Variable | Univariate analyses | Multivariate analyses | |||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| Age (≤65 vs. >65) | 0.967 (0.356–2.625) | 0.948 | |||
| Sex (female vs. male) | 1.161 (0.496–2.717) | 0.730 | |||
| Smoking (never vs. ever) | 1.023 (0.782–3.721) | 0.235 | |||
| Tumor size (≤2.0 vs. >2.0) | 3.851 (1.508–9.834) | 0.005 | 3.587 (0.982–8.831) | 0.067 | |
| N stage (N0-1 vs. N2) | 4.583 (1.888–11.128) | 0.001 | 4.087 (1.879–9.752) | 0.013 | |
| Histology (G vs. A)# | 2.759 (1.017–7.485) | 0.046 | 1.876 (0.763–6.734) | 0.276 | |
| Differentiation (W vs. P) | 2.468 (0.772–7.888) | 0.127 | |||
| LVI (− vs. +) | 3.771 (1.611–8.829) | 0.002 | 3.704 (1.187–11.557) | 0.024 | |
| VPI (− vs. +) | 2.383 (1.014–5.597) | 0.046 | 3.033 (0.912–9.091) | 0.068 | |
| ECOG (0-1 vs. 2) | 3.781 (0.903–5.385) | 0.125 | |||
| EGFR mutation (C vs. U) | 0.663 (0.183–2.400) | 0.531 | |||
| Her2 (− vs. +) | 0.535 (0.188–1.524) | 0.242 | |||
| Ki67 (≤10% vs. >10%) | 2.214 (0.912–5.375) | 0.079 | |||
| TTF1 (− vs. +) | 0.373 (0.083–1.677) | 0.199 | |||
| CK20 (− vs. +) | 1.009 (0.133–7.652) | 0.993 | |||
| CK7 (− vs. +) | 0.559 (0.149–2.104) | 0.390 | |||
| CK5/6 (− vs. +) | 4.874 (1.392–17.065) | 0.013 | 5.624 (1.577–20.054) | 0.028 | |
| P63 (− vs. +) | 1.703 (0.640–4.530) | 0.286 | |||
| RRM1 (− vs. +) | 25.460 (0.064–10,055.218) | 0.289 | |||
| NapsinA (− vs. +) | 0.785 (0.222–2.770) | 0.707 | |||
| Syn (− vs. +) | 0.040 (0.000–318.890) | 0.483 | |||
#, micropapillary subtype of invasive adenocarcinoma, solid subtype of invasive adenocarcinoma and adenosquamous lung carcinomas were defined as “aggressive” (A) tumor histology, while the others were defined as “general” (G). EGFR, epidermal growth factor receptor; HR, hazard ratios; CI, confidence intervals; LVI, lymphovascular invasion; VPI, visceral pleural invasion; ECOG, the Eastern Corporative Oncology Group; W, well/moderate; P, poor; C, common; U, uncommon.