Table S3. Multivariate competing risk analyses of independent indicators of site-specific recurrence.
| Variable | HR | 95% CI | P |
|---|---|---|---|
| Thoracic recurrence | |||
| Tumor size (≤2.0 vs. >2.0 cm) | 1.167 | 1.147–2.648 | 0.009 |
| Ki67 (≤10% vs. >10%) | 2.214 | 1.427–3.421 | 0.001 |
| Sex (female vs. male) | 1.671 | 1.103–2.517 | 0.036 |
| N stage (N0–1 vs. N2) | 1.643 | 1.128–2.837 | 0.028 |
| Histology (general vs. aggressive) | 1.578 | 0.862–3.553 | 0.193 |
| LVI (absence vs. presence) | 1.997 | 0.905–2.813 | 0.245 |
| VPI (absence vs. presence) | 1.649 | 0.782–2.422 | 0.337 |
| TTF1 (− vs. +) | 0.721 | 0.507–1.371 | 0.573 |
| CK20 (negative vs. positive) | 1.878 | 0.907–3.872 | 0.224 |
| CK7 (− vs. +) | 0.892 | 0.407–2.034 | 0.417 |
| CK5/6 (negative vs. positive) | 2.173 | 0.718–3.983 | 0.493 |
| Smoking (never vs. ever) | 1.21 | 0.916–1.726 | 0.118 |
| Brain recurrence | |||
| Tumor size (≤2.0 vs. >2.0 cm) | 9.273 | 1.374–72.12 | 0.031 |
| N stage (N0–1 vs. N2) | 3.721 | 1.172–11.97 | 0.038 |
| CK20 (negative vs. positive) | 4.271 | 1.452–13.18 | 0.017 |
| Syn (negative vs. positive) | 4.378 | 1.429–14.95 | 0.015 |
| Histology (general vs. aggressive) | 1.973 | 0.962–3.973 | 0.183 |
| LVI (absence vs. presence) | 2.436 | 0.783–3.263 | 0.318 |
| VPI (absence vs. presence) | 1.887 | 0.621–2.872 | 0.445 |
| Ki67 (≤10% vs. >10%) | 3.863 | 0.918–4.883 | 0.099 |
| Smoking (never vs. ever) | 0.907 | 0.815–1.252 | 0.137 |
| Bone recurrence | |||
| N stage (N0–1 vs. N2) | 4.027 | 1.966–8.248 | <0.001 |
| Ki67 (≤10% vs. >10%) | 2.345 | 1.091–5.039 | 0.029 |
| Tumor size (≤2.0 vs. >2.0 cm) | 2.167 | 0.982–5.234 | 0.108 |
| LVI (absence vs. presence) | 2.086 | 0.871–3.497 | 0.238 |
| VPI (absence vs. presence) | 2.357 | 0.924–4.872 | 0.372 |
| Abdominal recurrence | |||
| N stage (N0–1 vs. N2) | 11.047 | 2.891–42.209 | <0.001 |
| Tumor size (≤2.0 vs. >2.0 cm) | 5.236 | 0.783–10.237 | 0.127 |
| Differentiation (well/moderate vs. poor) | 4.371 | 0.639–18.473 | 0.378 |
| Ki67 (≤10% vs. >10%) | 4.872 | 0.579–11.238 | 0.381 |
| CK5/6 (negative vs. positive) | 5.269 | 0.421–17.215 | 0.457 |
| Neck recurrence | |||
| N stage (N0–1 vs. N2) | 15.236 | 4.607–50.390 | <0.001 |
| Tumor size (≤2.0 vs. >2.0 cm) | 5.792 | 0.892–10.378 | 0.218 |
| Differentiation (well/moderate vs. poor) | 4.831 | 0.736–11.861 | 0.387 |
| Histology (general vs. aggressive) | 2.871 | 0.674–9.763 | 0.217 |
| LVI (absence vs. presence) | 4.082 | 0.873–8.973 | 0.327 |
HR, hazard ratios; CI, confidence intervals; LVI, lymphovascular invasion; VPI, visceral pleural invasion.