Table 1. The results of two meta-analyses performed on the association between NAFLD and CVD mortality risk.

Meta-analyzes	Type of studies	Number of participants	Findings	HR (95% CI)
Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: a systematic review and meta-analysis (5)	21 cross-sectional studies	164,494, 89% men, mainly from Asia	No significant association was found between NAFLD and CVD mortality risk	1.10 (0.86–1.41)
	13 cohort studies		NAFLD was associated with an increased risk of prevalent CVD	1.81 (1.23–2.66)
			NAFLD was associated with an increased risk of incident CVD	1.37 (1.10–1.72)
Nonalcoholic fatty liver disease and risk of incident cardiovascular disease: a meta-analysis of observational studies (6)	6 community-based cohort	34,043, 46% men, mainly from Asia and USA	Patients with NAFLD had a higher risk of fatal and/or non-fatal CVD events than those without NAFLD More ‘severe’ NAFLD was associated to develop fatal and non-fatal CVD events	1.64 (1.26–2.13) 2.58 (1.78–3.75)
	5 outpatient cohort
	2 hospital-based-cohort
	3 selected cohort

NAFLD, nonalcoholic fatty liver disease; CVD, cardiovascular disease.