Figure 1.

Loss of malin in NSCLC accounts for a reduced histone acetylation and tumor progression. Malin is a RINGtype E3 ubiquitin ligase that promotes the ubiquitination and consecutive nuclear translocation of glycogen phosphorylase (GP) into the nucleus. GP catalyses the rate-limiting step in glycogenolysis by releasing glucose-1-phosphate (that after conversion in glucose-6-phosphate feeds glycolysis). In healthy lung, de novo synthesized nuclear glycogen provides, upon GP activity, a carbon pool for histone acetylation. In NSCLC, the loss of malin prevents nuclear glycogenolysis, in fine reducing histone acetylation and promoting tumor growth. NSCLC, non-small cell lung cancer.