Fig. 5.

KO genes encoded in the subgingival microbiome with different prevalence among clinical states and between T2DM and ND subjects. A total of 373 KO genes with different prevalence among the clinical states in T2DM and ND are shown. The bacterial species, which the KO genes belong to, are indicated by the color bars on the right according to Socransky’s designation of the bacterial complexes [37]. The KO genes labeled in brown are identified in the species from more than one microbial complex (more details in Supplementary Table 2)