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. 2020 Jan 22;10:973. doi: 10.1038/s41598-020-58009-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Determination by IC₅₀ of sacituzumab govitecan cytotoxicity compared to controls, ADC isotype and hRS7 IgG in cervical cancer. (A) Cervical cancer cell line with high Trop-2 expression (2 + ) (CVX8) demonstrated significantly lower IC₅₀ when compared to ADC isotype control (3.3 fold decrease, p < 0.05). (B) Cervical cancer cell line with high Trop-2 expression (2+) (ADX3) demonstrated significantly lower IC₅₀ when compared to ADC isotype control (1.9 fold decrease, p < 0.05). (C) Cervical cancer cell line with low/negligible Trop-2 expression (ADX2) showed no difference in the IC₅₀s of sacituzumab govitecan and ADC isotype control. hRS7 IgG antibody was inactive against these cell lines.