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. 2020 Jan 22;10:973. doi: 10.1038/s41598-020-58009-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bystander effect assay. (A) Low/negative Trop-2 expressing cells, ARK4 (GFP-ARK4 cells) co-cultured without any treatment (control), (B) Low Trop-2 expressing cells (ARK4 with GFP) co-cultured in 1:1 fashion with high Trop-2 expressing cells (CVX8), and treated with control ADC, (C) Low Trop-2 expressing cells (ARK4 with GFP) co-cultured in 1:1 fashion with high Trop-2 expressing cells (CVX8), and treated with sacituzumab govitecan. Significant increase in ARK4 cell cytotoxicity was detected at the time of the co-incubation with CVX8 cells (p = 0.02).