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. 2020 Jan 22;10:954. doi: 10.1038/s41598-020-57691-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compounds have diverse effects on viability, gene expression, and metabolite expression in the STHdh^Q111 cell model. (A) Cell viability assay categorizes 14 compounds as protective and 16 as unprotective. Data are represented as mean ± SD. *p-value < 0.001. The black, green, and gray bars indicate controls, protective compounds, and unprotective compounds, respectively. (B) The number of transcriptomic and metabolomic changes in compound-treated cells compared to controls.