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. 2020 Jan 22;10:954. doi: 10.1038/s41598-020-57691-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Omics profiles reveal unexpected similarities between compounds. (A) Clustering of metabolite profiling data reveals two distinct groups of compounds that are inseparable in the gene expression data, as displayed in t-SNE plots. The blue and red ellipses indicate the Group A and Group B compounds, respectively. Q7SST = STHdh^Q7 SST control; Q111SST = STHdh^Q111 SST control; Mec = meclizine; NaB = sodium butyrate; Cypro = cyproheptadine; Lox = loxapine; DOP = 4-deoxypyridoxine; Seli = selisistat; TSA = trichostatin A; DKI = diacylglycerol kinase inhibitor II; Nico = nicotinamide; Nort = nortriptyline; FTY720-P = fingolimod phosphate; Halo = haloperidol; Pizo = pizotifen; Cyst = cysteamine. (B) Clustering of proteomic data, as shown in three-dimensional PCA plots. See also Figs S1–S3, Tables S2–S6.