Table 5.
Transdermal group N = 66 | Vaginal group N = 92 | p | |
---|---|---|---|
Global satisfaction score (/10) | 8.2 ± 2 | 7.4 ± 2.2 | 0.04 |
No undesirable side effect noted | 26 (39.4) | 22 (23.9) | 0.04 |
One or many drawbacks of treatment noted | 16 (24.2) | 38 (41.3) | 0.03 |
Undesirable side effects noted by patients | |||
• Irritability | 10 (15.2) | 24 (26.1) | 0.1 |
• Headaches | 9 (13.6) | 12 (13.0) | 0.91 |
• Insomnia | 6 (9.1) | 8 (8.7) | 0.93 |
• Nausea | 6 (9.1) | 13 (14.1) | 0.34 |
• Diarrhea | 2 (3.0) | 4 (4.3) | 0.67 |
• Redness, itching at the application site | 11 (16.7) | 1 (1.1) | <0.001 |
• Acne | 4 (6.1) | 14 (15.2) | 0.07 |
• Dry skin | 5 (7.6) | 11 (12.0) | 0.37 |
• Back pain | 4 (6.1) | 8 (8.7) | 0.54 |
• Mastalgia | 6 (9.1) | 42 (45.7) | <0.001 |
• Fatigue | 18 (27.3) | 40 (43.5) | 0.037 |
• Other | 8(12.1) | 10(10.9) | 0.81 |
Mean number of side effects noted | 1.3 ± 1.5 | 2.5 ± 2.3 | <0.001 |
Data are expressed as n (%) or mean ± standard deviation.