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. 2020 Jan 22;10:985. doi: 10.1038/s41598-020-57730-3

Table 5.

Outcomes of patient satisfaction survey.

Transdermal group N = 66 Vaginal group N = 92 p
Global satisfaction score (/10) 8.2 ± 2 7.4 ± 2.2 0.04
No undesirable side effect noted 26 (39.4) 22 (23.9) 0.04
One or many drawbacks of treatment noted 16 (24.2) 38 (41.3) 0.03
Undesirable side effects noted by patients
• Irritability 10 (15.2) 24 (26.1) 0.1
• Headaches 9 (13.6) 12 (13.0) 0.91
• Insomnia 6 (9.1) 8 (8.7) 0.93
• Nausea 6 (9.1) 13 (14.1) 0.34
• Diarrhea 2 (3.0) 4 (4.3) 0.67
• Redness, itching at the application site 11 (16.7) 1 (1.1) <0.001
• Acne 4 (6.1) 14 (15.2) 0.07
• Dry skin 5 (7.6) 11 (12.0) 0.37
• Back pain 4 (6.1) 8 (8.7) 0.54
• Mastalgia 6 (9.1) 42 (45.7) <0.001
• Fatigue 18 (27.3) 40 (43.5) 0.037
• Other 8(12.1) 10(10.9) 0.81
Mean number of side effects noted 1.3 ± 1.5 2.5 ± 2.3 <0.001

Data are expressed as n (%) or mean ± standard deviation.