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. 2020 Jan 22;10:914. doi: 10.1038/s41598-020-57754-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characteristics of cultured platelets. (A) Platelet ultrastructure. Representative transmission electron microscopy (TEM) images of Native platelets (left panel, Bar = 1 µm) and Cultured platelets (right panel, Bar = 1 µm and 200 nm). (B) Quantification of MT coils. Numbers of microtubule coils in the marginal band on TEM images of thin sections of Native platelets and Cultured platelets. Values are the mean ± SEM for 40 and 82 platelets, n = 3, ns = not significant. (C) Quantification of granules. The densities of δ-granules, α-granules and multivesicular bodies (MVB) were quantified by TEM. Values are the density of granules reported to the platelet’s size ± SEM, ***p < 0.001, n = 70 and 95 for Native- and Cultured-Platelets respectively, n = 3. (D,E) Reticulated platelets. The bar graphs represent (D) the mean fluorescence intensity of thiazol orange (TO) staining in Native platelets or Cultured platelets reported to the platelet size represented by the forward scatter (FSC). (E) The bar graphs represent the percentage of platelets positive for TO and (F) the level of expression of the major surface glycoproteins.