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Possible underlying mechanisms of gender difference in ASCVD: estrogen, SIRT1, and eNOS
ASCVD: atherosclerotic cardiovascular disease; Sir1: sirtuin 1; Sir3: sirtuin 3; SERM: selective estrogen receptor modulator; ERAA: estrogen receptor agonist-antagonists; ERα: estrogen receptor α; ERβ: estrogen receptor β; Pcsk9: proprotein convertase subtilisin/kexin family 9; eNOS: endothelial nitric oxide synthase; ROS: reactive oxygen species; SOD: superoxide dismutase.
