Table 1.
Antinociceptive effects of DN‐9 and morphine in various pain models
| Pain models | Acute pain | Inflammatory pain | Neuropathic pain | |||
|---|---|---|---|---|---|---|
| Mechanical | Thermal | Cold | ||||
| ED50 for DN‐9 (μmol·kg−1) | Male | 0.22 (0.14–0.31) | 3.08 (2.55–3.67) | 3.32 (2.96–3.69) | 2.96 (2.43–3.56) | 0.25 (0.08–0.66) |
| Female | 0.22 (0.17–0.28) | 4.04 (3.12–5.05) | 3.42 (2.15–4.69) | 3.15 (1.67–4.40) | 0.29 (0.14–0.59) | |
| ED50 for Morphine (μmol·kg−1) | Male | 5.24 (4.57–5.95) | 8.05 (5.93–10.53) | 10.96 (3.31–46.35) | 10.13 (4.28–28.41) | 4.20 (3.08–5.26) |
Note. DN‐9 was injected s.c. in mice. The ED50 values were determined at the time of peak effects using non‐linear regression analysis.