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Representative RD (a, c, e, and g) and CEST (b, d, f, and h) profiles. The experimental CEST data at radio frequency fields of 13.6 and 27.2 Hz are indicated by “o” and “□” respectively. The solid lines are best fits obtained with a four-state model. The locations (or chemical shifts) of states N, I1, I2, and I3 in the CEST profiles are indicated by arrows. To see this figure in color, go online.
