Figure 3.

(A) Average Ca concentration c_i in the cytosol for high and low coupling fidelity. The concentration c_i is computed as the average diastolic Ca within all CRUs in the cell. (B) The corresponding voltage time course is shown. In these simulations, the last five beats are shown after pacing for 50 beats. (C) Average JSR load for nonjunctional CRUs as a function of coupling fidelity q is shown. Concentration is measured at the beginning of each beat. Concentrations shown are for the last 10 beats after pacing for 50 beats. (D) The average cytosolic Ca concentration at the beginning of each beat at nonjunctional CRUs is shown. (E) shows the same computation as in (C) but with a more extensive TT system, with $\langle n\rangle$ = 3. (F) APD vs. coupling fidelity q is shown. Parameters are the same as those used in (C). To see this figure in color, go online.