Figure 2.

Effects of nonspecific crowder interactions (ε) on the target search mode of DBPs. (A) The variation in the affinities of 1D and 3D search modes of the searching protein as a function of the ε is shown. (B) Variation in the average Z-displacement traversed by the Sap-1 protein per 1D event on the DNA surface as a function of ε is shown. The impact of nonspecific crowder interactions on the diffusivity of the searching protein is shown. (C) The variation in the relative 3D and (D) 1D diffusion coefficient of Sap-1 as functions of ε is shown. In (D), the associated error bars are smaller than the point size. D₀ represents the diffusion coefficients in the respective modes in the absence of crowder molecules. To see this figure in color, go online.