Figure 2.

Actions of IVM and FIP at b1 and c GluCl receptors. (a, b) Example currents obtained from oocytes expressing b1 GluCl receptors (a) and c GluCl receptors (b) in response to increasing concentrations of IVM. The IVM‐elicited currents were normalised to a saturating glutamate‐gated current (5 mM). (c) Group concentration–response plots of normalised IVM‐gated currents for b1 and c GluCl receptors fitted to Hill equations. The EC₅₀s were not significantly different, whereas the maximum current for the b1 GluCl receptors was significantly smaller. (d, e) Example currents gated by an EC₅₀ concentration of glutamate in response to increasing concentrations of FIP for b1 GluCl receptors (d) and c GluCl receptors (e). (f) Group concentration–response plots for inhibition by FIP, fitted to Hill equations. No significant difference was observed in EC₅₀s or maximum inhibition. The clamped membrane potential was −40 mV. Data points are means ± SEM