Figure 3.

Glutamate‐gated current inhibition by LND and PTX. (a, b) Example currents gated by an EC₅₀ concentration of glutamate in response to increasing concentrations of LND for b1 GluCl receptors (a) and c GluCl receptors (b). (c) Group concentration–response plots for inhibition by LND, fitted to Hill equations. The IC₅₀s were not significantly different, whereas the inhibition at maximum concentration of LND was significantly different. (d, e) Typical currents gated by an EC₅₀ concentration of glutamate in response to increasing concentrations of PTX for b1 GluCl receptors (d) and c GluCl receptors (e). (f) Group concentration–response plots for inhibition by PTX, fitted to Hill equations. The IC₅₀s were significantly different as was the inhibition at maximum concentration of PTX. The clamped membrane potential was −40 mV. Data points are means ± SEM