Figure 1.

Elevated renal CB₁ receptor (CB₁R) and inducible NOS (iNOS) protein expression in humans with chronic kidney disease. (a) Elevated protein expression levels of CB₁ receptors and iNOS were detected in 25 kidney biopsies from focal segmental glomerulosclerosis (FSGS), diabetic nephropathy (DN), and obesity‐related glomerulopathy (ORG) patients. (b, c) CB₁ receptors and iNOS are highly expressed in the kidney tubules in DN and ORG. Scale bar, 100 μm in all images except for the right panels in (b), where the scale is 50 μm. Data represent the mean ± SEM from six normal, eight DN, and 10 ORG kidney samples. ^* P < .05, significantly different from normal kidney; one‐way ANOVA, followed by a Bonferroni post hoc test