Figure 2.

MRI‐1867 improves the metabolic profile in diet‐induced obese mice. Male mice on standard diet (STD) or high‐fat diet (HFD) for 18 weeks were treated with vehicle (Veh) or MRI‐1867 (3 mg·kg⁻¹) orally for 28 days. MRI‐1867 reduced (a, b) the body weight, (c) daily, and (d) the total food intake but not (e) the water intake. Metabolically, MRI‐1867 decreased (f, g) the respiratory quotient, which indicates a higher fat utilization, and increased (h, i) total energy expenditure (TEE) and (j, k) fat oxidation, without affecting (l, m) carbohydrate oxidation. Data represent the mean ± SEM from 8 to 14 mice per group. ^* P < .05, significantly different from animals on STD; ^# P < .05, significantly different from animals on the same diet; one‐way ANOVA, followed by a Bonferroni post hoc test