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. 2019 Dec 27;32:160–167. doi: 10.1016/j.molmet.2019.12.012

Figure 4.

Figure 4

GAS5 and gene expression changes in islets from diabetic donors, GK islets, and beta cells under glucotoxic conditions. A. Expression of GAS5 in islets from control (ND) (n = 10) and T2D donors (n = 9) as measured by qPCR assay. B. GAS5 expression in islets vs HbA1c levels in all of the donors (n = 19). C. GAS5 expression in the islets of T2D model GK rats. D. Glucose regulation of GAS5 in EndoC-βH1 cells (n = 4) exposed to glucotoxic conditions. E. GR protein expression. F. Protein expression of PDX1. G. Protein expression of NKX6-1 and SYT13. The data are presented as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001.