Figure 6.

Progesterone, Myc Inhibitor, and Isoflavones Have a Potential to Reduce Mammary Dysplasia Formation

C57BL/6J mice were administered E2 in combination with PG, KJ, Eq. or Ge. for 30 days. Fluorescent images of CK8 and CK5 staining are shown. Mammary ducts with intraductal and extraductal expansion were quantified (n = 6 mice, one-way ANOVA followed by Tukey's test and U Mann-Whitney test). Scale bars, 30 μm. Error bars represent standard deviation. In the graphs, crosses with different colors indicated the values of different animals. Eq., (S)-equol; Ge., genistein; KJ, KJ-Pyr-9.