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. 2019 Nov 8;10(1):42–60. doi: 10.1016/j.apsb.2019.11.002

Figure 5.

Figure 5

Relative levels of Insig 1 and Insig 2 and SREBP-1c proteins in INH-treated Chip-KO and Gp78-KO mouse hepatocytes and corresponding WT-controls: Hepatocytes were cultured for 48 h and then treated with INH for 3 days (as in Fig. 3). Lysate proteins (5 or 15 μg for Insig or SREBP-1c, respectively) were subjected to immunoblotting analyses with corresponding antibodies. P, precursor, N, nuclear SREBP-1c species identified on the basis of their corresponding molecular weights. For detailed methodology see Supporting Information. These data are unpublished findings by Kwon & Correia, 2019.