Diversity and distance of the microbial community in each group. (A) The Shannon indexes of the Han4k_6d, Han4k, and Han4k_b3m groups were significantly lower than those of the Han1k and Tibetan4k groups. The FDR-corrected P values shown were based on the Mann-Whitney U test with multiple-testing correction. (B) PCoA based on the unweighted UniFrac distances of the microbial communities between samples. The Han1k, Han4k, and Tibetan4k groups were representative and different from each other. Han4k_4d and Han4k_6d were closer to Han4k than to Han1k, and Han4k_b3m was closer to Han4k than to Han1k. (C) UPGMA tree based on the unweighted UniFrac distances between groups. (D) Unweighted UniFrac distances of different groups from the Han4k and Han4k_b3m groups. Statistical significance was labeled only for comparisons of interest.