. 2020 Jan 22;11:2042018819897527. doi: 10.1177/2042018819897527

Table 1.

Reported drug influence on body weight in clinical trials.

	Drugs leading to weight gain	Weight gain in kg	Possible alternative	Weight loss in kg
Antiepileptics/mood stabilizer	Valproate	1.2–5.8^a	Zonisamide	−7.7
	Gabapentin	2.2	Topiramate	−3.8
	Lithium	4.0^a	Lamotrigine	±0
	Carbamazepine	1.0^a
Neuroleptics	Olanzapine	2.4	Ziprasidone	−3.2 to −2.7^a
	Quetiapine	1.1	Ziprasidone	−3.2 to −2.7^a
	Risperidone	0.8
	Clozapine	4.2 to 9.9^a
	Aripiprazole	0.6^a
Glucocorticoids	Class effect with approximately 4–8% increase in body weight
Antidiabetics	Insulin	1.8–6.5^a
	Glimepiride	2.1	Metformin	−1.1
	Glibenclamide	2.6	Acarbose	−0.4
	Pioglitazone	2.6	GLP1-agonists	−1.2 to −5.6
	Tolbutamide	2.8	SGLT2-Inhibitors	−2.2 to −4.7
	Sitagliptin	0.55
	Nateglinide	0.3
Antidepressives	Nortriptyline	3.7^a	Bupropion	−1.3
	Doxepine	2.7^a	Fluoxetine	−1.3
	Amitriptyline	1.8	Sertraline	(unknown)
	Mirtazapine	1.5	Venlafaxine	(unknown)
			Duloxetine	(unknown)
Betablockers	Atenolol	1^a	(ACE-Inhibitors)^b	+/–0
	Metoprolol	0.5–1.5^a	(AT1-Blockers)^b	+/–0
	Propranolol	−0.6 to 2.3^a	(Thiazides)^b	+/–0

Adapted from Pilitsi and colleagues,⁸ Domecq and colleagues,³⁷ and Leslie and colleagues.⁴⁸

Limited or no data available from randomized placebo controlled trials and measured weight change.

No effect on body weight but with metabolically favorable or at least neutral (thiazides) profile.

ACE, angiotensin-converting enzyme; AT1-Blockers, angiotensin II receptor antagonists; GLP1, glucagon-like peptide-1 receptor; SGLT2, sodium-glucose transport protein 2.