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. 2020 Jan 23;19:13. doi: 10.1186/s12943-020-1139-3

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Expression profiles of circRNAs in CRC and characterization of circPTK2. a Heatmap of the differentially expressed circRNAs in six pairs of human CRC tissues and adjacent non-tumor tissues. Red: upregulated circRNAs in CRC; green: downregulated circRNAs in CRC. b circPTK2 is back-spliced by exons 27, 28, and 29 of PTK2. c, d Cells were treated with hypoxia. circPTK2 was detected by RNAscope. Location and expression of circPTK2 in SW620 and LOVO cells. e, f Location and expression of circPTK2 in SW480 and HCT15 cells. g Location and expression of circPTK2 in adjacent and tumor of patient tissue. P values were calculated by one-way ANOVA